Pseudotumor cerebri and slipped capital femoral epiphysis have been reported in pediatric patients receiving thyroid replacement therapy. The usual maintenance dose is 25 mcg to 75 mcg once daily. Monitor for cardiac arrhythmias during surgical procedures in patients with coronary artery disease receiving suppressive liothyronine sodium therapy. Call your doctor for medical advice about side effects. The objective of this study was to investigate the bioequivalence of Mylan's liothyronine sodium 50 mcg tablets to King's Cytomel 50 mcg tablets following a single, oral 100 mcg (2 x 50 mcg) dose administration under fasting conditions. Serum TSH levels should be monitored and the liothyronine sodium dosage adjusted during pregnancy. If you miss a dose, take it as soon as you remember. Because of the increased prevalence of cardiovascular disease among the elderly, initiate liothyronine sodium at less than the full replacement dose [see Dosage and Administration (2.3) and Warnings and Precautions (5.1)]. Liothyronine is the most potent form of thyroid hormone. Liothyronine doses are based on weight (especially in children and teenagers). Enter your medication into the WebMD interaction checker, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Fitness vs. Liothyronine sodium may reduce the therapeutic effects of digitalis glycosides. Common side effects of liothyronine may include: This is not a complete list of side effects and others may occur. Prescription Settings generic tablet 5mcg Liothyronine sodium is a synthetic (man-made) version of one of the two hormones made by the thyroid gland, triiodothyronine. Different brands of liothyronine may not work the same. The amino acid tyrosine is iodinated and coupled in the human . Ghaziabad, Uttar Pradesh. Indications and Usage for Liothyronine Liothyronine sodium injection (T 3) is indicated in the treatment of myxedema coma/precoma. Treatment should be initiated immediately upon diagnosis and maintained for life, unless transient hypothyroidism is suspected, in which case, therapy may be interrupted for 2 to 8 weeks after the age of 3 years to reassess the condition. Liothyronine Sodium Tablets, USP are intended for oral administration; once-a-day dosage is recommended. It can also be used to test for certain types of thyroid disease.This medication should not be used to treat infertility unless it is caused by low thyroid hormone levels. Addition of thyroid hormone therapy in patients with diabetes mellitus may worsen glycemic control and result in increased antidiabetic agent or insulin requirements. Each round, white to off-white Cytomel (liothyronine sodium) tablet contains liothyronine Administer liothyronine sodium at least 4 hours prior to these drugs or monitor thyrotropin-stimulating hormone (TSH) levels. Usual maintenance dose is 50 to 100 mcg daily. Signup. Instruct patients to notify their healthcare provider if they are taking any other medications, including prescription and over-the-counter preparations. Cytomel (liothyronine sodium) is a synthetic thyroid hormone used to treat hypothyroidism (low thyroid hormone). USP Reference standards 11 USP Levothyroxine RS. Properly discard this product when it is expired or no longer needed. Administer thyroid hormone products formulated for intravenous administration to treat myxedema coma. Thus, they exert a profound influence on every organ system in the body and are of particular importance in the development of the central nervous system. Do not take more or less of it or take it more often than prescribed by your doctor. Pregnancy may increase liothyronine sodium requirements. Consult your doctor before breast-feeding. Since postpartum TSH levels are similar to preconception values, the liothyronine sodium dosage should return to the pre-pregnancy dose immediately after delivery [see Dosage and Administration (2.3)]. Therefore, patients without a functioning thyroid gland who are on thyroid replacement therapy may need to increase their thyroid dose if estrogens or estrogen-containing oral contraceptives are given. Untreated maternal hypothyroidism may have an adverse effect on fetal neurocognitive development. In the US - Call your doctor for medical advice about side effects. At 1 year, 50 mcg daily may be required. This product may contain inactive ingredients, which can cause allergic reactions or other problems. It re. L-Triodotironin Sodium 25mg, 100 tablets (Abdi Ibrahim) Tiromel (T3), brand name for substance liothyronine sodium is a thyroid hormone. Liothyronine Sodium Tablets, USP may be used in preference to levothyroxine (T4) during radioisotope scanning procedures, since induction of hypothyroidism in those cases is more abrupt and can be of shorter duration. Liothyronine sodium has a narrow therapeutic index. You can take liothyronine either before or after meals. Thyroid hormones may increase the risk of coronary insufficiency when sympathomimetic agents are administered to patients with coronary artery disease. Thyroid USP contains not less than (NLT) 0.17 percent and not more than (NMT) 0.23 percent iodine, and thyroglobulin contains not less than (NLT) 0.7 percent of organically bound iodine. ANALYSIS(16714-166, 16714-167, 16714-168), MANUFACTURE(16714-166, 16714-167, 16714-168), Liothyronine sodium tablets are not indicated for suppression of benign thyroid nodules and nontoxic diffuse goiter in iodine-sufficient patients as there are no clinical benefits and overtreatment with liothyronine sodium may induce hyperthyroidism. It is best to take it at the same time each day so your thyroid hormone level is kept at a constant level. The liver is the major site of degradation for both T4 and T3. Labeler Index. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Keep using this medicine as directed, even if you feel well. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Overtreatment may accelerate the bone age and result in premature epiphyseal closure and compromised adult stature. Liothyronine sodium injection (T 3) can be used in patients allergic to desiccated thyroid or thyroid extract derived from pork or beef. Neither is their use justified for the treatment of male or female infertility unless this condition is accompanied by hypothyroidism. In these patients, liothyronine sodium therapy should be initiated with low doses, with due consideration for its relatively rapid onset of action. Cessation of therapy is justified in patients who have maintained a normal TSH during those 2 to 8 weeks. Save money on your Cytomel Tablets prescription by switching to Teva's FDA-approved generic version, Liothyronine Sodium Tablets USP We recommend using a newer internet browser, such as Google Chrome or Microsoft Edge, to optimize your browsing experience. Dosing must be individualized to account for these factors and dose adjustments made based on periodic assessment of the patient's clinical response and laboratory parameters [see Dosage and Administration (2.4)]. As pituitary thyroid-stimulating hormone (TSH) suppressants, in the treatment or prevention of various types of euthyroid goiters, including thyroid nodules, subacute or chronic lymphocytic thyroiditis (Hashimoto's) and multinodular goiter. When 25 mcg daily is reached, dosage may be increased every week or two by 12.5 or 25 mcg. We comply with the HONcode standard for trustworthy health information. Liothyronine Sodium Liothyronine is a man-made form of a hormone that is normally produced by your thyroid gland to regulate the body's energy and metabolism. In addition, confusion and disorientation may occur. 131I uptake is determined before and after the administration of the exogenous hormone. Cardiac glycosides may be indicated if congestive heart failure develops. Animal studies have not been performed to evaluate the carcinogenic potential, mutagenic potential or effects on fertility of liothyronine sodium. Call +91-7942544680. The images and information for a particular product may change over time. Do not stop taking it without first talking with your doctor. a condition with low thyroid hormone levels. Careful observation is required. Intracellular resistance to thyroid hormone is quite rare. Severe and prolonged hypothyroidism can lead to a decreased level of adrenocortical activity commensurate with the lowered metabolic state. US residents can call their local poison control center at 1-800-222-1222. A very serious allergic reaction to this drug is rare. This hormone nuclear receptor complex activates gene transcription and synthesis of messenger RNA and cytoplasmic proteins. No special precautions appear to be necessary when oral anticoagulant therapy is begun in a patient already stabilized on maintenance thyroid replacement therapy. While the general aim of therapy is to normalize the serum TSH level, TSH may not normalize in some patients due to in utero hypothyroidism causing a resetting of pituitary-thyroid feedback. Package insert / prescribing information In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. Liothyronine is a man-made form of a hormone that is normally produced by your thyroid gland to regulate the body's energy and metabolism. Therefore, in severe and prolonged hypothyroidism, supplemental adrenocortical steroids may be necessary. When administered to patients on a thyroid preparation, this parenteral anesthetic may cause hypertension and tachycardia. Do not take two doses at one time. Adverse reactions, other than those indicative of hyperthyroidism because of therapeutic overdosage, either initially or during the maintenance period are rare (see OVERDOSAGE). Liothyronine is used to treat an underactive thyroid (hypothyroidism).It replaces or provides more thyroid hormone, which is normally made by the thyroid gland.Liothyronine is a man-made form of . Initiating thyroid replacement therapy may cause increases in insulin or oral hypoglycemic requirements. Monitor for the presence of drug or food interactions when using liothyronine sodium and adjust the dose as necessary [see Drug Interactions (7) and Clinical Pharmacology (12.3)]. Short-term administration of large doses of glucocorticoids may decrease serum T3 concentrations by 30% with minimal change in serum T4 levels. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Thyroid hormones increase the metabolism (activity) of all cells in the body. Titrate the dose of liothyronine sodium carefully and monitor response to titration to avoid these effects [see Dosage and Administration (2.4)]. Liothyronine is used to treat an underactive thyroid (hypothyroidism). 71335-0341. Adverse reactions associated with liothyronine sodium therapy are primarily those of hyperthyroidism due to therapeutic overdosage [see Warnings and Precautions (5.4) and Overdosage (10)]. Liothyronine comes as a tablet to take by mouth. At all times, close monitoring of urinary glucose levels is mandatory in such patients. 3. Tell your doctor if you are pregnant because your doctor may need to change your dose. The hormones contained in the natural preparations are absorbed in a manner similar to the synthetic hormones. Cytomel ( liothyronine sodium) is a synthetic (man-made) version of one of the two hormones made by the thyroid gland, triiodothyronine, used to treat individuals who are hypothyroid (do not produce enough thyroid hormones) and prevent various types of euthyroid goiters. For elderly patients or patients with underlying cardiac disease, start with liothyronine sodium tablets 5 mcg once daily and increase by 5 mcg increments at the recommended intervals. If you notice other effects not listed above, contact your doctor or pharmacist. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. On the basis of current knowledge, thyroid replacement therapy to hypothyroid women should not be discontinued during pregnancy. Currently. 25 mcg tablets are white to off white, oval shaped, uncoated tablets, debossed with '583' on one side and scored on the other side. It usually is taken once daily. The higher affinity of levothyroxine (T4) for both thyroid-binding globulin and thyroid-binding prealbumin as compared to triiodothyronine (T3) partially explains the higher serum levels and longer half-life of the former hormone. Thyroid replacement treatment is usually taken for life. For the most up-to-date product information, please contact Sigmapharm Laboratories, LLC. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Hypersensitivity reactions to inactive ingredients have occurred in patients treated with thyroid hormone products. Liothyronine sodium has a rapid onset of action and residual effects of the other thyroid preparation may persist for the first several weeks after initiating liothyronine sodium therapy. Treatment is symptomatic and supportive. Liothyronine Sodium Tablets, USP should be administered cautiously to patients in whom there is a strong suspicion of thyroid gland autonomy, in view of the fact that the exogenous hormone effects will be additive to the endogenous source. Familial hyper- or hypo-thyroxine binding globulinemias have been described, with the incidence of TBG deficiency approximating 1 in 9000. Changes in TBg concentration should be taken into consideration in the interpretation of T, Medicinal or dietary iodine interferes with all. Although liothyronine sodium has a rapid cutoff, its metabolic effects persist for a few days following discontinuance. You may need to stop for a short time. Store between 15C and 30C (59F and 86F). Pharmacological action1: Liothyronine sodium is a naturally occurring thyroid hormone. Concurrent use of tricyclic (e.g., amitriptyline) or tetracyclic (e.g., maprotiline) antidepressants and liothyronine sodium may increase the therapeutic and toxic effects of both drugs, possibly due to increased receptor sensitivity to catecholamines. Thyroid hormones play an important role in your overall health. Patients stabilized on oral anticoagulants who are found to require thyroid replacement therapy should be watched very closely when thyroid is started. NDC 68382-582-01 in bottles of 100 tablets with child-resistance closure. Failure of the serum TSH to decrease below 20 IU per liter after initiation of liothyronine sodium therapy may indicate the child is not receiving adequate therapy. They help support metabolism and energy levels. Closely monitor infants during the first 2 weeks of thyroid hormone therapy for cardiac overload, arrhythmias, and aspiration from avid suckling. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This survey is being conducted by the WebMD marketing sciences department. When switching a patient to Liothyronine Sodium Tablets, USP from thyroid, L-thyroxine or thyroglobulin, discontinue the other medication, initiate Liothyronine Sodium Tablets, USP at a low dosage, and increase gradually according to the patient's response. Bile acid sequestrants and ion exchange resins are known to decrease thyroid hormones absorption. Assess compliance, dose of medication administered, and method of administration prior to increasing the dose of liothyronine sodium [see Warnings and Precautions (5.1) and Use in Specific Populations (8.4)]. Mild Hypothyroidism Recommended starting dosage is 25 mcg daily. For thyroid problem diagnosis: Adults 75 to 100 micrograms (mcg) once a day for 7 days. In patients with primary hypothyroidism, maintain serum TSH in the trimester-specific reference range. It replaces or provides more thyroid hormone, which is normally made by the thyroid gland. For pediatric patients three years of age and older, the recommended monitoring is every 3 to 12 months thereafter, following dose stabilization until growth and puberty are completed. Liothyronine Sodium is a thyroidal hormone T3 which is normally produced by the thyroid gland in a ratio 4:1 when compared with T4: T3. Peptide Steroid Hormones [553] Peptide Growth Hormone [39] Bodybuilding Human Growth Hormone [33 . Thyroid hormone preparations are generally contraindicated in patients with diagnosed but as yet uncorrected adrenal cortical insufficiency, untreated thyrotoxicosis and apparent hypersensitivity to any of their active or extraneous constituents. Starting dosage of Liothyronine Sodium Tablets, USP is 5 mcg daily, and should be increased by no more than 5 mcg increments at 2-week intervals. To check the immediate response to therapy before the TSH has had a chance to respond or if your patient's status needs to be assessed prior to that point, measurement of total T3 would be most appropriate. Actions of particular beta-adrenergic antagonists may be impaired when a hypothyroid patient is converted to the euthyroid state. Glass Vial Labels [174] Steroid Vial Labels . You may not be able to use liothyronine if you have an adrenal gland problem that is not controlled by treatment. Infants a few months old may require 20 mcg once daily for maintenance. Ghaziabad Radhey Sham Vihar, Ghaziabad - 201009, Dist. Specific measurements of T4 and T3 by competitive protein binding or radioimmunoassay are not influenced by blood levels of organic or inorganic iodine and have essentially replaced older tests of thyroid hormone measurements, i.e., PBI, BEI and T4 by column. T3 is further deiodinated to diiodothyronine. Both protein-bound hormones exist in reverse equilibrium with minute amounts of free hormone, the latter accounting for the metabolic activity. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Vomiting may be induced initially if further gastrointestinal absorption can reasonably be prevented and barring contraindications such as coma, convulsions, or loss of the gagging reflex. Take the tablets with a drink of water. Experience with liothyronine use in pregnant women, including data from post-marketing studies, have not reported increased rates of major birth defects or miscarriages (see Data). Myxedematous patients are very sensitive to thyroid; dosage should be started at a very low level and increased gradually. Cytomel is also used to treat or prevent goiter ( enlarged thyroid gland ), and is also given as part of a medical tests for thyroid disorders. Thyroxine increases the adrenergic effect of catecholamines such as epinephrine and norepinephrine. Headache, irritability, nervousness, sweating, arrhythmia (including tachycardia), increased bowel motility and menstrual irregularities. Pregnancy, infectious hepatitis, estrogens, estrogen-containing oral contraceptives, and acute intermittent porphyria increase TBG concentrations. When given as part of a thyroid suppression test, you will need to take liothyronine for several days in a row in preparation for the test. For patients with serum TSH above the normal trimester-specific range, increase the dose of thyroid hormone and measure TSH every 4 weeks until a stable dose is reached and serum TSH is within the normal trimester-specific range. Product Info . Liothyronine sodium has a rapid cutoff of activity which permits quick dosage adjustment and facilitates control of the effects of overdosage, should they occur. Liothyronine Sodium Tablets, USP contain liothyronine (L-triiodothyronine or LT3), a synthetic form of a natural thyroid hormone, and is available as the sodium salt. Administer the minimum dose of liothyronine sodium that achieves the desired clinical and biochemical response to mitigate against this risk. An intravenous preparation of liothyronine sodium is marketed under the trade name Triostat for use in myxedema coma/precoma. For Suppliers. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function. Instruct patients that liothyronine sodium tablets should only be taken as directed by their healthcare provider. *Cytomel is a registered trademark of Pfizer, Inc. Liothyronine Sodium Tablets, USP (25 mcg), Liothyronine Sodium Tablets, USP (50 mcg). NDC 16714-168-01 in bottles of 100 tablets with child-resistance closure. Dosage should be reduced or therapy temporarily discontinued if signs and symptoms of overdosage appear. These medications may cause some risk when taken together. If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Cytomel (liothyronine sodium) Tablets are intended for oral administration; once-a-day dosage is recommended. The dose of liothyronine sodium should target TSH levels within the desired therapeutic range. Contact Supplier Request a quote . Thyroid hormonal replacement increases metabolic rate, which requires an increase in digitalis dosage. Also call your doctor at once if you have: chest pressure spreading to your jaw or shoulder; a light-headed feeling, like you might pass out; severe headaches, ringing in your ears, dizziness, vision problems, pain behind your eyes; (in a child or teenager) pain, stiffness, and trouble moving the legs. Having enough thyroid hormone helps you stay healthy. Liothyronineis used to treat an underactive thyroid(hypothyroidism). Therefore, 4 to 5 hours should elapse between administration of cholestyramine and thyroid hormones. Gradually increase the liothyronine sodium dose according to the patient's response. Medically reviewed by Drugs.com on Feb 11, 2022. Drugs with thyroid hormone activity, alone or together with other therapeutic agents, have been used for the treatment of obesity. Even if you have no symptoms, tests can help your doctor determine if this medicine is effective. Get savings updates for Cytomel (liothyronine) Receive price alerts, news, and other messages from GoodRx about Cytomel (liothyronine) and other healthcare topics and relevant savings offers. Login. Recommended starting dosage is 5 mcg daily, with a 5 mcg increment every 3 to 4 days until the desired response is achieved. Liothyronine sodium is contraindicated in patients with uncorrected adrenal insufficiency [see Warnings and Precautions (5.3)]. At 1 year of age, 50 mcg once daily may be required. 1 INDICATIONS AND USAGE 1.1 Hypothyroidism - Liothyronine Sodium Tablets, USP are indicated as a replacement therapy in primary (thyroidal), secondary (pituitary), and tertiary (hypothalamic) congenital or acquired . The major pathway of thyroid hormone metabolism is through sequential deiodination. T4 and T3 are produced in the human thyroid gland by the iodination and coupling of the amino acid tyrosine. T3 contains three atoms of iodine and is formed by the coupling of one molecule of DIT with one molecule of monoiodotyrosine (MIT). Follow all directions on your prescription label and read all medication guides or instruction sheets. Pre-existing Hypothyroidism: Thyroid hormone dose requirements may increase during pregnancy. Liothyronine Sodium Tablet. White Round 582 - Liothyronine Sodium 5mcg Tablet. Follow your doctor's instructions about using this medicine if you are pregnant. Dose adjustments during pregnancy and the postpartum period. Reduce thyroid hormone dosage to pre-pregnancy levels immediately after delivery and measure serum TSH levels 4 to 8 weeks postpartum to ensure thyroid hormone dose is appropriate. Popular Products of T3 Oral Bodybuilding Tablets 40mcg/Tablet Quality Triiodothyronine Sodium Origin China by Oral Anabolic Steroids - Doublewin Biological Technology Co., Ltd. from China. 3375 Progress Dr If cardiovascular symptoms develop or worsen, reduce or withhold the liothyronine sodium dose for one week and restart at a lower dose. Nephrosis, severe hypoproteinemia, severe liver disease, acromegaly, androgens and corticosteroids decrease TBG concentration. Written by Cerner Multum. The following drugs or moieties are known to interfere with laboratory tests performed in patients on thyroid hormone therapy: androgens, corticosteroids, estrogens, oral contraceptives containing estrogens, iodine-containing preparations and the numerous preparations containing salicylates. An initial increase in serum FT4 is followed by return of FT4 to normal levels with sustained therapeutic serum salicylate concentrations, although total T4 levels may decrease by as much as 30%. T4 and T3 are produced . These hormones enhance oxygen consumption by most tissues of the body, increase the basal metabolic rate and the metabolism of carbohydrates, lipids and proteins. Potential impact: Stimulation of hepatic microsomal drug-metabolizing enzyme activity may cause increased hepatic degradation of thyroid hormones, resulting in increased liothyronine sodium requirements. Liothyronine treats hypothyroidism ( low thyroid hormone). The therapy of myxedema coma requires simultaneous administration of glucocorticoids. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Congenital Hypothyroidism [see Dosage and Administration (2.2, 2.6)]. Serum T4 levels can be used to test the effectiveness of all thyroid medications except products containing liothyronine sodium. Medically reviewed by Drugs.com. Thyroid hormones, including CYTOMEL, should not be used for the In rare instances, allergic skin reactions have been reported with Liothyronine Sodium Tablets, USP. In a patient with a nonfunctioning thyroid gland who is receiving thyroid replacement therapy, free levothyroxine may be decreased when estrogens are started thus increasing thyroid requirements. Take your next dose at the regular time. Thyroid hormones, including liothyronine sodium tablets, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss. The dosage of thyroid hormones is determined by the indication and must in every case be individualized according to patient response and laboratory findings. The TSH suppression test can be used to test the effectiveness of any thyroid preparation, bearing in mind the relative insensitivity of the infant pituitary to the negative feedback effect of thyroid hormones. However, you may not be able to use this medicine if you have an adrenal gland problem that is not controlled by treatment. Administration of sertraline in patients stabilized on liothyronine sodium may result in increased liothyronine sodium requirements. Liothyronine Sodium By Avanscure Lifesciences Pvt. HAZARDS IDENTIFICATION Measures to control fever, hypoglycemia, or fluid loss should be instituted if needed. 1.3 Thyroid Suppression Test Liothyronine sodium tablets are indicated as a diagnostic agent in suppression tests to differentiate suspected mild hyperthyroidism or thyroid gland autonomy. THYROID PREPARATIONS/BILE ACID SEQUESTRANTS . Certain medications can decrease the absorption of liothyronine. Estrogens tend to increase serum thyroxine-binding globulin (TBg). Approximately 80% of circulating T3 is derived from peripheral T4 by monodeiodination. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Liothyronine sodium tablets, USP are supplied as follows: 5 mcg tablets are white to off white, round, flat faced beveled edge, uncoated tablets, debossed with '582' on one side and plain on the other side.