It is currently being evaluated in multiple phase 2 clinical trials. Jan Oliver, Illustrator. Today, our virology pipeline has active clinical and pre-clinical studies in the areas of Hepatitis B virus (HBV) and pan-coronavirus. This cookie is set by GDPR Cookie Consent plugin. On the latest episode of the Hidden Track Podcast, Sarah Houle-Lowry and Shane . Nine patients entered the follow-up period, currently ranging from 12 to 44 weeks, after stopping all therapies. We are currently conducting IND-enabling studies with AB-101 that we anticipate completing this year.. AB-729 targets hepatocytes using Arbutus novel covalently conjugated N-Acetylgalactosamine (GalNAc) delivery technology enabling subcutaneous delivery. With respect to the forward-looking statements contained in this press release, Arbutus has made numerous assumptions regarding, among other things: the effectiveness and timeliness of preclinical studies and clinical trials, and the usefulness of the data; the timeliness of regulatory approvals; the continued demand for Arbutus' assets; and . As mentioned in our press release dated June 25, 2022, Arbutus decided to dose a new cohort of healthy volunteers for a longer period in the AB-836-001 clinical trial to clarify the earlier safety signal seen in cHBV patients in the same trial. The cookie is used to store the user consent for the cookies in the category "Other. We store over 100,000 individual books, have 42 fine authors, arrange many book signings, events, interviews, and press releases. We also have an ongoing drug discovery and development program directed to identifying novel, orally active agents for treating coronavirus (including SARS-CoV-2). Get the latest Arbutus Biopharma Corporation (ABUS) stock news and headlines to help you in your trading and investing decisions. Help Noi, di Yahoo, facciamo parte della famiglia di brand di Yahoo. Arbutus Announces Three Poster Presentations with Clinical Data from AB-729 and Preclinical Data from AB-101 at AASLD - The Liver Meeting 2022. Simply Wall St . The patients are continuing to be followed. AB-101 Preclinical DataA preclinical study was conducted to assess the ability of monotherapy and combination treatment with AB-101, a small molecule oral PD-L1 inhibitor, and an HBV-targeting RNAi agent, to reinvigorate HBV-specific T-cell activity in an HBV mouse model. By clicking Accept All, you consent to the use of ALL the cookies. You also have the option to opt-out of these cookies. However, you may visit "Cookie Settings" to provide a controlled consent. All of the data will be presented as poster presentations at AASLD The Liver Meeting being held in Washington, DC, November 4-8, 2022. "We are pleased to be granted this key patent by the USPTO which expands our intellectual property estate and adds a level of protection for a fundamental asset of our chronic hepatitis B virus (cHBV) portfolio," said William Collier, President . Create your Watchlist to save your favorite quotes on Nasdaq.com. This cookie is set by GDPR Cookie Consent plugin. Arbutus Announces Three Poster Presentations with Clinical Data from AB-729 and Preclinical Data from AB-101 at AASLD - The Liver Meeting 2022. Based on the attributes of AB-729 that we have seen thus far, I believe that AB-729 will be a major contributor to future HBV curative regimens.. An archived webcast will be available on the Arbutus website after the event. A broad and innovative virology portfolio. Stocks Features Premarket . Blog. Analytical cookies are used to understand how visitors interact with the website. With respect to the forward-looking statements contained in this press release, Arbutus has made numerous assumptions regarding, among other things: the effectiveness and timeliness of preclinical studies and clinical trials, and the usefulness of the data; the timeliness of regulatory approvals; the continued demand for Arbutus' assets; and . We have identified a class of small molecule oral PD-L1 inhibitors that we believe will allow for controlled checkpoint blockade, enable oral dosing, and mitigate systemic safety issues typically seen with checkpoint antibody therapies. The cookies is used to store the user consent for the cookies in the category "Necessary". We also use third-party cookies that help us analyze and understand how you use this website. Hepatitis B virus (HBV) therapeutic success requires a multi-faceted approach. The data continues to demonstrate that AB-729 is capable of achieving long-lasting control of HBV biomarker levels after discontinuation of nucleoside therapy, most likely as a result of AB-729-induced HBV-specific immunological control. Boost and reawakenthe hosts immune response. . WARMINSTER, Pa., Aug 30, 2022 (GLOBE NEWSWIRE via COMTEX) -- WARMINSTER, Pa., Aug. 30, 2022 (GLOBE NEWSWIRE) -- Arbutus Biopharma Corporation (Nasdaq: ABUS),. Press Releases. WARMINSTER, Pa., Oct. 26, 2022 (GLOBE NEWSWIRE) Arbutus Biopharma Corporation ( Nasdaq: ABUS ), a clinical-stage biopharmaceutical company leveraging its extensive virology expertise to develop novel therapeutics that target specific viral diseases, today announced that it has scheduled its third quarter 2022 financial results and corporate . With respect to the forward-looking statements contained in this press release, Arbutus has made numerous assumptions regarding, among other things: the effectiveness and timeliness of preclinical studies and clinical trials, and the usefulness of the data; the timeliness of regulatory approvals; the continued demand for Arbutus assets; and the stability of economic and market conditions. Just like our namesake Arbutus, a healing plant native to North America, we are leveraging our growing innovative portfolio of assets to focus our efforts on treating and curing conditions with unmet medical need. This cookie is set by GDPR Cookie Consent plugin. Preliminary data from sixty-five patients randomized to receive AB-729+VBR+NA (n=32), AB-729+NA (n=17) or VBR+NA (n=16) for 48 weeks showed that adding VBR to AB-729+NA does not result in greater on-treatment improvements in markers of HBV infection as compared to AB-729+NA alone. Hepatitis B is a potentially life-threatening liver infection caused by the hepatitis B virus (HBV). As mentioned in our press release dated June 25, 2022, Arbutus decided to dose a new cohort of healthy volunteers for a longer period in the AB-836-001 clinical trial to clarify the earlier safety signal seen in cHBV patients in the same trial. Few viruses have had a more pervasive impact around the globe than SARS-CoV-2. Press Releases. Dr. Gaston Picchio, Chief Development Officer of Arbutus Biopharma, stated, I remain impressed with the longer follow up data we generated from our AB-729-001 trial. Based on the compilation of safety and efficacy data achieved to-date, we are confident in AB-729s potential role as a cornerstone agent in a curative combination treatment for chronic hepatitis B virus infection (cHBV), said William Collier, Arbutus President and Chief Executive Officer. The cookie is set by GDPR cookie consent to record the user consent for the cookies in the category "Functional". WTFC. Additionally, there are known and unknown risk factors which could cause Arbutus actual results, performance or achievements to be materially different from any future results, performance or achievements expressed or implied by the forward-looking statements contained herein. Nasdaq provides press releases highlighting valuable information sent out by companies. Arbutus Press Arbutus | Press Release | Feb 1 Baltimore County Government: Amid Encouraging Progress In COVID-19 Metrics, Baltimore County . Combination treatment with AB-101 and an HBV targeting GalNAc-siRNA agent resulted in activation and increased frequency of HBV-specific T-cells and greater anti-HBsAg antibody production. Our three-pronged Suppress, Reduce, Boost method harnesses multiple agents with complementary mechanisms of action to maximize impact. The cookie is used to store the user consent for the cookies in the category "Analytics". Press Release Desk, News Partner. You'll now be able to see real-time price and activity for your symbols on the My Quotes of Nasdaq.com. Year: - Any -. Out of these, the cookies that are categorized as necessary are stored on your browser as they are essential for the working of basic functionalities of the website. Here you can find the companys latest financial figures, contact information, and source version of the press release to stay ahead of the market for value generation. AB-729-001 Clinical Trial Data In the AB-729-001 clinical trial, patients with cHBV who completed 48 weeks of treatment with AB-729, and 24 weeks later met protocol-defined criteria to also stop nucleos(t)ide analogue (NA) therapy, were evaluated during an extended follow-up period to assess HBV biomarkers and ALT levels. Other Events. Gaston Picchio, PhD, Chief Development Officer, to Depart Arbutus at Year End . As mentioned in our press release dated June 25, 2022, Arbutus decided to dose a new cohort of healthy volunteers for a longer period in the AB-836-001 clinical trial to clarify the earlier safety . October 3, 2022 - TheNewswire - Vancouver, British Columbia - Arctic Star Exploration Corp. ("Arctic Star" or the "Company") (TSXV:ADD) (Frankfurt:82A2) (WKN:A2DFY5) (OTC:ASDZF) is pleased to announce diamond indicator mineral "DIMS" analysis and classification has . Touch device users, explore by touch or with swipe gestures. Per maggiori informazioni su come utilizziamo i tuoi dati, consulta la nostra Informativa sulla privacy e la nostra Informativa sui cookie. All seven patients had detectable HBeAg and therefore did not meet the protocol-defined NA discontinuation criteria. WARMINSTER, Pa., Aug. 30, 2022 (GLOBE NEWSWIRE) -- Arbutus Biopharma Corporation (Nasdaq: ABUS), a clinical-stage biopharmaceutical company leveraging its extensive virology expertise to develop novel therapeutics that target specific viral diseases, today announced that the United States Patent and Trademark Office (USPTO) issued U.S. Patent . Edward Ritts, author. ARBUTUS BIOPHARMA CORPORATION : Press releases relating to ARBUTUS BIOPHARMA CORPORATION Investor relations | London Stock Exchange: 0SGC | London Stock Exchange No safety events were noted during the follow-up period for this cohort. Focused on combination regimens for maximum impact. The patent is expected to provide Arbutus with exclusivity for AB-729 out to at least April 2038. On October 31, 2022, Arbutus Biopharma Corporation ("the Company") issued a press release announcing that the Company will be presenting three posters with clinical data from its lead clinical compound, AB-729, an RNAi therapeutic, and its preclinical oral PD-L1 inhibitor, AB-101, at The American Association for the Study of Liver Diseases (AASLD) - The Liver Meeting . Press Release Desk, News Partner. In this healthy volunteer arm, two subjects dosed with AB-836 experienced low grade ALT elevations after more than 20 days of dosing, causing the Company to stop dosing. Outsmart the market with Smart Portfolio analytical tools powered by TipRanks. SEC Filings. All forward-looking statements herein are qualified in their entirety by this cautionary statement, and Arbutus disclaims any obligation to revise or update any such forward-looking statements or to publicly announce the result of any revisions to any of the forward-looking statements contained herein to reflect future results, events or developments, except as required by law. William H. CollierPresident and CEOPhone: 267-469-0914Email: ir@arbutusbio.com, Lisa CaperelliVice President, Investor Relations Phone: 215-206-1822Email: lcaperelli@arbutusbio.com, Arbutus Presents AB-729 Clinical Data andAB-101 Preclinical Data at AASLD - The Liver Meeting. ET. Known risk factors include, among others: anticipated pre-clinical studies and clinical trials may be more costly or take longer to complete than anticipated, and may never be initiated or completed, or may not generate results that warrant future development of the tested product candidate; Arbutus may elect to change its strategy regarding its product candidates and clinical development activities; Arbutus may not receive the necessary regulatory approvals for the clinical development of Arbutus products; economic and market conditions may worsen; uncertainties associated with litigation generally and patent litigation specifically; Arbutus and its collaborators may never realize the expected benefits of the collaborations; market shifts may require a change in strategic focus; and the ongoing COVID-19 pandemic could significantly disrupt Arbutus clinical development programs. Forward-looking statements in this press release include statements about our future development plans for our product candidates; the expected cost, timing and results of our clinical development plans and clinical trials with respect to our product candidates; our expectations with respect to the release of data from our clinical trials and the expected timing thereof; our expectations and goals for our collaborations with third parties and any potential benefits related thereto; and the potential for our product candidates to achieve success in clinical trials. A live webcast of the conference call can be accessed through the Investors section of Arbutus' website at www.arbutusbio.com. Three patients experienced transient HBV DNA elevations that spontaneously resolved without intervention, which further supports AB-729's potential for immunological control. 8-K: Arbutus Biopharma Corp. Immune checkpoints such as PD-1/PD-L1 play an important role in the induction and maintenance of immune tolerance and in T-cell activation. Arbutus | Press Release | Dec 4 Baltimore County Police: County Detectives Investigate Circumstances Surrounding Shooting. We are proud of our robust internal research capabilities, which have yielded an impressive portfolio of assets for the treatment of diverse viral diseases. More ABUS Latest News > Latest News Feed. It does not store any personal data. In the same trial, a cohort of seven HBeAg positive patients who received 90 mg of AB-729 every 8 weeks (Cohort K) was also assessed. With respect to the forward-looking statements contained in this press release, Arbutus has made numerous assumptions regarding, among other things: the effectiveness and timeliness of preclinical studies and clinical trials, and the usefulness of the data; the timeliness of regulatory approvals; the continued demand for Arbutus' assets; and . The cookie is set by the GDPR Cookie Consent plugin and is used to store whether or not user has consented to the use of cookies. ARBUTUS BIOPHARMA CORPORATION : Press releases relating to ARBUTUS BIOPHARMA CORPORATION Investor relations | Deutsche Boerse AG: I9DN | Deutsche Boerse AG The World Health Organization estimates that over 290 million people worldwide suffer from chronic HBV infection, while other estimates indicate that approximately 2.4 million people in the United States suffer from chronic HBV infection. ABUS. Hard cover, color, 9 x 12/ $17.95. We are committed to harnessing combination drug development to attack different aspects of viruses and diseases and to elevate the convenience of finite treatments. Dr. Michael J. Sofia, Chief Scientific Officer of Arbutus Biopharma, stated, The HBV immune enhancement seen with AB-101 further supports our development strategy of using AB-101 in combination with AB-729 and other approved and investigational agents to potentially achieve a functional cure in cHBV patients. We use cookies on our website to give you the most relevant experience by remembering your preferences and repeat visits. We believe AB-101, when used in combination with other approved and investigational agents, could potentially allow us to realize our mission of achieving a functional cure for HBV chronically infected patients. Based on these additional safety findings, the Company has decided to discontinue clinical development of AB-836. Our current focus areas include Hepatitis B virus (HBV), SARS-CoV-2, and other coronaviruses. AB-729 is currently in multiple Phase 2a clinical trials. One patient reached HBeAg less than lower levels of quantitation (LLOQ) intermittently. A more complete discussion of the risks and uncertainties facing Arbutus appears in Arbutus Annual Report on Form 10-K, Arbutus Quarterly Reports on Form 10-Q and Arbutus continuous and periodic disclosure filings, which are available at www.sedar.com and at www.sec.gov. Type a symbol or company name. Arbutus carnival 2022. Our team includes leaders with the deep scientific and commercial expertise needed to accelerate and strengthen our robust portfolios path to market. Activity for your symbols on the latest episode of the conference call can accessed... More pervasive impact around the globe than SARS-CoV-2 Noi, di Yahoo facciamo!, our virology pipeline has active clinical and pre-clinical studies in the areas of hepatitis B is a life-threatening! To harnessing combination drug development to attack different aspects of viruses and diseases and elevate! Can be accessed through the Investors section of Arbutus ' website at www.arbutusbio.com globe than.... 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